Figure 1.

Volcano plot and multidimensional scaling analyses for mRNA, miRNA, and miRNA-targeted mRNA expressions of the RNA-seq validation cohort

(A) Volcano plot representing the differentially expressed mRNA and miRNA expressions in COVID-19 compared with the healthy control subjects. Among the differentially expressed RNA expressions, 1,906 mRNA and 14 miRNA expressions were upregulated and 1,039 mRNA and 20 miRNA expressions were downregulated. The significant differentially expressed RNA expressions are indicated. The vertical dotted lines represent |log2 fold change| >0.6. The horizontal dotted line represents the threshold for FDR < 0.1. Red dots indicate upregulated RNA expressions, and blue dots indicate downregulated RNA expressions. (B) Multidimensional scaling plot of all mRNA, miRNA, and miRNA-targeted mRNA expressions in COVID-19 compared with the healthy control subjects.