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. 2022 Jun 29;13:908815. doi: 10.3389/fimmu.2022.908815

Figure 2.

Figure 2

Characterizations of circulating monocytes in patients with and without plaque rupture. (A) t-SNE plot showing re-clustering of monocyte cells into 12 clusters. (B) Expression t-SNE plot of monocytes markers CD14 and FCGR3A (CD16). (C) t-SNE plot of monocytes divided into three cell types: classical, intermediate, and non-classical monocytes. (D) t-SNE plot showing contribution of monocytes for patients with PR and NPR. (E) Percentage of monocytes subtype in patients with PR and NPR. (F) Heatmap showing expression levels of discriminative genes for each cluster. (G) GSEA heatmap of total cluster in monocytes. (H, I) Prototypical pro-inflammatory hub genes such as CCL5, TLR7, and CX3CR1 identified by STRING and Cytoscape were significantly upregulated in classical and non-classical monocytes derived from patients with PR. (J) Top GO terms of classical monocytes in patients with PR. (K) Top GO terms of non-classical monocytes in patients with PR.