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. 2022 Jun 29;13:908815. doi: 10.3389/fimmu.2022.908815

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Copyright © 2022 Qian, Gao, Lai, Ye, Yao, Ding, Tong, Lin, Zhu, Yu, Ding, Yuan, Chu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterizations of T cells in patients with and without plaque rupture. (A) t-SNE plot showing re-clustering of T cells into 17 clusters and t-SNE plot of patients with PR and NPR. (B) Expression t-SNE plot of T cell marker genes as CD4, CD8A, CCR7, CXCR3, FOXP3 and KLRG1. (C) Percentage of T cell subtype in patients with PR and NPR. (D) t-SNE plot showing the contribution of different T cell subsets. (E) Heatmap showing expression levels of discriminative genes for each cluster. (F) GSEA heatmap of T cell clusters. (G) GO analysis of upregulated genes in CD4⁺ effector T cells from patients with PR. (H) Expression of pro-inflammatory hub genes such as CCL5, CXCR3, NKG7, S100A8, S100A9, and LYZ were significantly upregulated in CD4⁺ effector T cells of patients with PR.