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. 2022 Jun 29;13:908815. doi: 10.3389/fimmu.2022.908815

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Copyright © 2022 Qian, Gao, Lai, Ye, Yao, Ding, Tong, Lin, Zhu, Yu, Ding, Yuan, Chu, Chen and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Characterization of NK cells in patients with and without plaque rupture. (A) t-SNE plot showing the re-clustering of NK cells into 9 clusters and t-SNE plot of patients with PR and NPR. (B) Expression t-SNE plot of NK cell marker genes as FCGR3A, CD8A, and NCAM1. (C) t-SNE plot showing the contribution of different NK cell subsets. (D) Percentage of NK cell subtypes in patients with PE and PR. (E) Heatmap showing expression levels of discriminative genes for each cluster. (F) GO analysis of upregulated genes in CD16^bright NK, CD16^dim NK, and NKT cells. (G) Expression of pro-inflammatory hub genes such as S100A9, LYZ, and TNFAIP3 were significantly upregulated in CD16^bright NK cells of patients with PR.