TABLE 4.

Model parameter definitions, population (n = 21) fits, and average male and average female fit values

Parameter	Definition	Full cohort (n = 21)	Comment	Avg male response (n = 13)	Avg female response (n = 8)
β	Per target cell attachment rate	1.5 × 10−5	Reference 62	1.39 × 10−5	1.49 × 10−5
D	Target cell death rate	0.33	Reference 62	0.37	0.4
E	Eclipse rate	4	Reference 62	4.1	3.71
B	Infected cell budding rate	1,115,038	Reference 62	1.06 × 107	1.11 × 107
C	Virion clearance rate	0.76	Fixed	0.78	0.59
δ	Rate of CD4+ T cell priming	0.0083	Fit	0.0082	0.0072
${\alpha }_{\text{TI}}$	CD4+ T cell priming enhancement due to IL-2	0.000003	Fit	2.96 × 10−6	2.85 × 10−6
sI	CD4+ duplication threshold due to IL-2	593	Fixed	593	593
${\alpha }_{\text{TF}}$	CD4+ T cell priming enhancement due to IFN-γ	1.2 × 10−6	Fit	1.22 × 10−6	1.23 × 10−6
sF	CD4+ T cell duplication threshold due to IFN-γ	627	Fixed	627	627
${\gamma }_{\text{T}}$	CD4+ T cell death rate	0.001 to 0.7	Fixed range	0.0061	0.0032
${\mu }_{\text{IT}}$	IL-2 stimulation rate by CD4+ T cells	0.0065	Fit	0.0066	0.0064
${\alpha }_{\text{IT}}$	IL-2 clearance by CD4+ T cells	4.9 × 10−7	Fit	4.83 × 10−7	4.96 × 10−7
${\gamma }_{\text{I}}$	IL-2 natural degradation rate	0.096	Fit	0.1	0.1
${\mu }_{\text{FT}}$	IFN-γ stimulation rate by CD4+ cells	3.21	Fit	3.23	3.14
${\alpha }_{\text{FT}}$	IFN-γ clearance by CD4+ T cells	0.00022	Fit	0.0002	0.0002
${\gamma }_{\text{F}}$	IFN-γ natural degradation rate	56.57	Fit	56.57	57.58
${\mu }_{\text{GT}}$	GzmB stimulation rate by CD4+ cells	0.18	Fit	0.2	0.25
${\gamma }_{\text{G}}$	GzmB natural degradation rate	2.45	Fit	2.93	2.46
ε	Fraction of infection virions	0.001	Reference 62	0.001	0.001
${\mu }_{\text{GyB}}$	Rate of GzmB-infected cell killing	0.0079	Fit	0.014	0.074
BIC	Bayesian information criteria	2,258	Fit
AIC	Akaike information criteria	2,219	Fit