FIG 7.

The antiviral mechanism of FUBP3 can inhibit PEDV replication. During PEDV infection, host cells recognize the virus and activate TCFL5 to upregulate the abundance of FUBP3. FUBP3 interacts with E3 ubiquitin ligase MARCHF8 to ubiquitin N protein, then recruiting the cargo receptor NDP52 to recognize the ubiquitinated N protein and deliver it to autophagosome for degradation. Additionally, TARDBP activates type I IFN signaling by directly targeting TRAF3, which then induces the phosphorylation of TBK1.