Table 1.
IC50 and pI of proteins/polypeptides
| Proteins/Polypeptides | IC 50 (μM) | SE | pI * |
Electronic charge
at pH = 7** |
||
|---|---|---|---|---|---|---|
| Examined in this study | Salivary | Neutrophil elastase (29 kDa***) | 0.03 | 1.08 | 9.71 | + |
| Lysozyme C (17 kDa***) | No inhibition | 9.38 | + | |||
| Neutrophil defensin-1 (10 kDa***) | Faint inhibition (~20>) | 6.54 | +/− | |||
| Histone H2A type 1 (14 kDa****) | ~0.62 | 1.09 | 10.90 | + | ||
| Manufactured | α-Poly-L-lysine (2.6 kDa) | 1.02 | 2.23 | 11.18 | + | |
| ε-Poly-L-lysine (4.5 kDa) | 0.07 | 1.06 | ~11.5 | + | ||
| α-Poly-L-arginine (>70 kDa) | <0.28 | 1.09 | >13.6 | + | ||
| α-Octa-L-arginine (>1.4 kDa) | Faint inhibition | 12.85 | + | |||
| Related to this study | Paneth cell defensin-5 (10 kDa***) | 8.30 | + | |||
| ACE peptidase domain | 5.04 | − | ||||
| S1 receptor binding domain | 8.91 | + |
*Theoretical values of respective proteins with the full-length.
**Estimated from pI.
***The full-length.
****The full-length but not degraded length (~6 kDa).