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. 2022 Jul 11;11(1):2094583. doi: 10.1080/2162402X.2022.2094583

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© 2022 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Cytokine levels of plasma from Mlh1^−/− and Msh2^{loxP/loxP;TgTg(Vil}¹^−cre) mice. (a) Mlh1^−/− and (b) Msh2.^{loxP/loxP;TgTg(Vil1−cre)} Plasma samples were collected before treatment (= baseline) and at the experimental endpoint. Cytokine levels were determined as described in material and methods. Given is the x-fold change of the indicated marker in comparison to day 0 (= baseline). Mlh1^−/−: ctrl: n = 3, isotype: n = 3, α-PD-L1 n = 7, abemaciclib: n = 6, combination n = 5. Msh2^{loxP/loxP VillinCre}: ctrl: n = 4, isotype: n = 7, α-PD-L1 n = 6, abemaciclib: n = 9, combination n = 8. *p < .05; ***p < .001, Kruskal-Wallis test (Dunn’s multiple comparisons test). (a-b) All data are given as mean + SEM.