Figure 4.
Network analyses of the risk genes
(A) The co-expression relationships between top 30 ASD and ID risk genes in PFC-MSC 4–6 region. This is found as the informative co-expression network for DeepND and is also indicated in the literature as an important window for ASD.43 Only links for at least 0.95 absolute correlation and genes with at least one connection are shown.
(B) The protein-protein interactions between the top-percentile risk genes are shown. The protein-protein interactions (PPIs) are obtained from the tissue-specific PPI network of frontal cortex in the DifferentialNet database.53 Only interactions between the top-percentile risk genes are shown.