Figure 4.

BRD4 genomic distribution in NF2-null Schwann cells. BRD4 was chromatin immunoprecipitated from hSC2λ-shNF2 Schwann cells treated with DMSO or JQ1 (1 µM) and total BRD4 peaks mapped to GRCh38/hg38. (A) Distribution of BRD4 peaks (BRD4 ChIP vs input) (top) and BRD4 peaks sensitive to JQ1 treatment (BRD4 ChIP DMSO vs BRD4 ChIP JQ1) (bottom), relative to gene bodies. Shown are pie charts of peak enrichment relative to genomic location (peak annotation visualization, PAVIS) (B) GO annotation of biological process of genes associated with JQ1-sensitive BRD4 peaks. (C) Gene list of JQ1-sensitive BRD4 binding peaks, classified into functionally related groups by GO term annotation.