Table 1.
Recipient characteristics at time of lung transplant
| Subgroups Defined by BMI at Transplant |
All (N = 1,977) | |||
|---|---|---|---|---|
| ⩾18.5 kg/m2 (n = 1,256) | 17–18.49 kg/m2 (n = 449) | <17 kg/m2 (n = 272) | ||
| Male sex, n (%) | 715 (57) | 226 (50) | 118 (43) | 1,059 (54) |
| Age, yr, median (IQR) | 31 (26–39) | 27 (23–33) | 25 (22–30) | 29 (24–37) |
| Race, n (%) | ||||
| White | 1,236 (98) | 438 (98) | 267 (98) | 1,942 (98) |
| African American | 14 (1) | 9 (2) | —* | 25 (1) |
| Hispanic | 46 (4) | 17 (4) | 6 (2) | 69 (3) |
| Other | 9 (1) | 6 (1) | 5 (2) | 20 (1) |
| Private insurance, n (%) | 732 (58) | 253 (56) | 163 (60) | 1,148 (58) |
| CF mutation class, n (%) | ||||
| 1–3, high risk | 888 (71) | 313 (70) | 195 (72) | 1,397 (71) |
| 4–5, low risk | 79 (6) | 11 (2) | 11 (4) | 101 (5) |
| Not yet classified | 141 (11) | 58 (13) | 39 (14) | 238 (12) |
| Other | 148 (12) | 67 (15) | 27 (10) | 242 (12) |
| Pancreatic insufficiency, n (%) | 1,233 (99) | 446 (100) | 268 (99) | 1,948 (99) |
| Height, cm, mean (SD) | 167 (9) | 166 (9) | 166 (8) | 167 (9) |
| Weight, kg, median (IQR) | 58 (52–66) | 49 (45–53) | 44 (41–48) | 54 (48–61) |
| BMI, kg/m2, median (IQR) | 21 (19–22) | 18 (17–18) | 16 (16–17) | 19 (18–21) |
| Functional status, n (%) | ||||
| Unknown | 11 (1) | 10 (2) | —* | 24 (1) |
| 10%: Moribund, fatal processes progressing rapidly | 57 (5) | 18 (4) | 13 (5) | 88 (4) |
| 20%: Very sick, hospitalization necessary: active treatment necessary | 168 (13) | 51 (11) | 54 (20) | 273 (14) |
| 30%: Severely disabled: hospitalization is indicated, death not imminent | 84 (7) | 25 (6) | 24 (9) | 133 (7) |
| 40%: Disabled: requires special care and assistance | 207 (16) | 90 (20) | 49 (18) | 346 (17) |
| 50%: Requires considerable assistance and frequent medical care | 185 (15) | 62 (14) | 43 (16) | 290 (15) |
| 60%: Requires occasional assistance but is able to care for needs | 224 (18) | 76 (17) | 29 (11) | 330 (17) |
| 70%: Cares for self: unable to carry on normal activity or active work | 178 (14) | 71 (16) | 31 (11) | 280 (14) |
| 80%: Normal activity with effort: some symptoms of disease | 99 (8) | 32 (7) | 15 (6) | 146 (7) |
| 90%: Able to carry on normal activity: minor symptoms of disease | 31 (2) | 10 (2) | 7 (3) | 48 (2) |
| 100%: Normal, no complaints, no evidence of disease | 12 (1) | 4 (1) | —* | 20 (1) |
| Diabetes status, n (%) | ||||
| None documented | 344 (28) | 117 (26) | 89 (33) | 550 (28) |
| Impaired glucose tolerance | 110 (9) | 43 (10) | 18 (7) | 172 (9) |
| Diabetes | 794 (64) | 289 (64) | 165 (61) | 1,248 (63) |
| Insulin status, n (%) | ||||
| No CFRD treatment | 362 (29) | 134 (30) | 89 (33) | 585 (30) |
| Dietary change or oral hypoglycemic agents | 49 (4) | 20 (4) | 12 (4) | 81 (4) |
| Intermittent insulin (e.g., with illness, steroids) | 50 (4) | 22 (5) | 15 (6) | 88 (4) |
| Chronic insulin | 787 (63) | 273 (61) | 156 (57) | 1,216 (62) |
| HbA1c, %, median (IQR) | 6.3 (5.7–7.1) | 6.3 (5.8–6.9) | 6.2 (5.7–7.3) | 6.3 (5.7–7.0) |
| Lung allocation score, median (IQR) | 40 (37–48) | 42 (38–50) | 45 (39–68) | 41 (37–50) |
| FEV1 percent predicted, median (IQR) | 22 (18–27) | 21 (18–25) | 20 (17–25) | 21 (18–26) |
| Length of stay from treatment to discharge, d, median (IQR) | 17 (12–26) | 16 (13–24) | 18 (14–29) | 17 (12–26) |
Definition of abbreviations: BMI = body mass index; CF = cystic fibrosis; CFRD = cystic fibrosis–related diabetes; FEV1 = forced expiratory volume in 1 second; HbA1c = hemoglobin A1c; IQR = interquartile range; SD = standard deviation.
*
Values < 5 were suppressed to avoid identification of individuals within the cohort.