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. Author manuscript; available in PMC: 2022 Jul 13.
Published in final edited form as: Ultrasound Med Biol. 2019 Nov 5;46(2):193–215. doi: 10.1016/j.ultrasmedbio.2019.09.011

Figure 4.

Figure 4.

Confocal laser scanning micrographs of in vitro, propidium iodide (red) stained, Pseudomonas aeruginosa PAO1:gfp-2 biofilms following treatment with a) nothing (control), b) ultrasound and Definity® (microbubble), c) gentamicin (antibiotic) alone, and d) gentamicin, ultrasound, and Definity®. The top panel is the top-down maximum intensity projection and the bottom panel is the corresponding three-dimensional volume rendering. Ultrasound parameters were 0.5 MHz at 1.1 MPa peak negative pressure with a 16-cycle tone burst and pulse repetition frequency of 1 kHz for 5 minutes (reprinted with permission from Ronan et al. (2016)).