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. 2022 Mar 1;65(5):3798–3813. doi: 10.1021/acs.jmedchem.1c01995

Table 5. SAR of the 5-Aryl Group in Combination with the 4-Hydroxy-4-aminomethyl-piperidine Side Chain.

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a

Hep CLint: In vitro hepatocyte clearance. PPB: Plasma protein binding. Cmax, AUC, T1/2: from mean blood concentration time profile of oral administration in rats at 10 mg/kg.