Table 2.
Tumor and Treatment Characteristics of Abstainers and Continued Smokers
| Abstainers, n=517 | Continued Smokers, n=533 | ||||
|---|---|---|---|---|---|
| Variable | No. | % | No. | % | P * |
| Site of primary tumor | |||||
| Nasopharynx | 0 | 0 | 1 | 3 | .87 |
| Oropharynx | 11† | 64.7 | 20 | 60.6 | |
| Hypopharynx | 1 | 5.8 | 3 | 9.1 | |
| Larynx | 5 | 29.4 | 9 | 27.3 | |
| Tumor grade/differentiation ‡ | |||||
| Well/moderately well | 2 | 11.8 | 3 | 9.1 | .53 |
| Moderate | 7 | 41.1 | 17 | 51.5 | |
| Poor/moderately poor | 7 | 41.1 | 8 | 24.2 | |
| Tumor classification | |||||
| T0-T2 | 7 | 41.1 | 18 | 54.5 | .37 |
| T3-T4 | 10 | 58.9 | 15 | 45.5 | |
| Lymph node status | |||||
| N0 | 5 | 29.4 | 11 | 33.3 | .78 |
| N1-N3 | 12 | 70.6 | 22 | 66.7 | |
| Overall stage | |||||
| I | 2 | 11.8 | 4 | 12.1 | .44 |
| II | 0 | 0 | 4 | 12.1 | |
| III | 5 | 29.4 | 6 | 18.1 | |
| IV | 10 | 58.8 | 19 | 57.7 | |
| Treatment | |||||
| XRT alone | 7 | 41.1 | 10 | 30.3 | .57 |
| Ind. CTX→XRT | 0 | 0 | 3 | 9.1 | |
| Concurrent CTX-XRT | 7 | 41.1 | 15 | 45.5 | |
| Ind. CTX→CTX-XRT | 3 | 17.8 | 5 | 15.1 | |
| No CTX | 7 | 41.1 | 10 | 30.3 | .44 |
| Received CTX | 10 | 58.8 | 23 | 69.7 | |
| Variable | Mean ± SD | Median (Range) | Mean ± SD | Median (Range) | P |
| Radiation dose, Gy | 68.3 ± 3.3 | 70 (63–72) | 68.9 ± 4.3 | 70 (48–72) | .65 |
| No. of radiation fractions | 32.9 ± 3.17 | 33 (30–42) | 33.2 ± 5.0 | 33 (12–42) | .84 |
| Radiation schedule, d | 44.2 ± 4.3 | 44 (39–51) | 43.9 ± 2.9 | 44 (38–51) | .40 |
| Follow-up, d | 533.4 ± 227.4 | 519 (103–1026) | 515.8 ± 395.0 | 395.7 (111–1210) | .60 |
XRT indicates radiation therapy; CTX, chemotherapy; Ind., induction; SD, standard deviation; Gy, grays.
The chi-square or the Fisher exact test was used for categorical variables, as appropriate, and t tests were used to compare means (with adjustment for unequal variances, as appropriate) for continuous variables.
Includes 1 patient who had cervical metastasis of unknown primary origin. Radiation fields for this patient were consistent with oropharyngeal fields.
Tumor grade was not recorded for 1 abstainer and for 5 continued smokers; moderately to well differentiated was listed as well differentiated, and moderately to poorly differentiated was listed as poorly differentiated.