Figure 2.

Gastrin-SiO₂ microspheres attenuates the sodium-induced increase in blood pressure (BP). A, Protocol for gastrin-SiO₂ microspheres generation and intestinal location in vivo; gastrin-SiO₂ microspheres location determined by fluorescence emission tomography. B, Immunofluorescence of stomach and jejunum in the 2 groups of mice (n=3/group, *P<0.05 vs control). C and D, Gastrin-SiO₂ microspheres ameliorated the high salt (HS)-elevated systolic BP and urine Na concentration in Dahl salt-sensitive rats fed normal (N, 0.49% NaCl) or HS (8% NaCl) diets (*P<0.05 vs Dahl salt-sensitive control [normal-salt diet], # vs Dahl salt-sensitive + HS diet, 1-way ANOVA, Tukey test). E, Urine potassium excretion was not different among the groups. FITC indicates fluorescein isothiocyanate.