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. 2022 Jun 8;79(8):1668–1679. doi: 10.1161/HYPERTENSIONAHA.121.18791

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© 2022 The Authors.

Hypertension is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 3. — Gastrin/CCKBR (cholecystokinin B receptor) decreases Na+/H+ exchanger 3 (NHE3) expression and activity in intestinal brush border membrane. A, Immunofluorescence of Alexa Fluor 488-labeled CCKBR (green), and Alexa Fluor 568-labeled NHE3 (red) in human intestine (scan bar is 200 μm) and mouse jejunum (scan bar is 75 μm). B and C, NHE3 expression in the 3 intestinal segments in knockout (KO) and wild-type (WT) mice fed normal (N) or high (H) salt diet (n=4/group, *P<0.01 vs Cckbr^fl/fl WT, 1-way ANOVA, Holm-Sidak test). D, Immunofluorescence of Alexa Fluor 488-labeled F-actin (green) and Alexa Fluor 568-labeled NHE3 (red) in Dahl salt-sensitive rats (scan bar is 200 μm). E, Immunofluorescence of Alexa Fluor 488-labeled NHE3 (green) in WT and KO mice (scan bar is 100 μm).