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. 2022 Jul 13;8(28):eabm3596. doi: 10.1126/sciadv.abm3596

Fig. 5. Clustering M3P into submicrometric particles improves sensitivity of molecular MRI of VCAM-1.

Fig. 5.

(A) Top: Schematic representation of the particles. Middle: Representative T2*-weighted images after intravenous injection of the corresponding particles (4 mg/kg) 24 hours after injection of 1 μg of LPS in the right striatum. Bottom: Representative phase microscopy images of the particles after conjugation to control IgG or anti–VCAM-1 antibodies. (B) Corresponding quantification (n = 4 per group). (C) Schematic representation of the findings that large M3P (700 nm) provides better sensitivity than small M3P (300 nm). *P < 0.05.