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. 2022 Jul 13;8(28):eabn8063. doi: 10.1126/sciadv.abn8063

Fig. 1. Overview of the CID25-ACKR3·CXCL12-CID24 complex (PDB entry 7SK3).

Fig. 1.

(A) Cryo-EM map contoured at 10 σ (left) and corresponding atomic model (right). CRL, cholesterol. (B) Interactions of ACKR3 (orange cartoon) with CXCL12 (green cartoon). The N terminus of the receptor contributes an extra strand to the core β sheet of the chemokine, whereas the N terminus of CXCL12 extends into the orthosteric pocket of the receptor. (C) CDR-H3 of the heavy chain of CID25 (gray cartoon with magenta CDR-H3) interacts with ECL2 of the receptor (orange cartoon) and the 30s loop of chemokine (shown in green cartoon). (D) CDR-H3 of the heavy chain of CID24 (blue cartoon with magenta CDR-H3) inserts into the cytoplasmic pocket of the active receptor.