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. 2022 Mar 15;13(3):6579–6589. doi: 10.1080/21655979.2022.2038434

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — DSF/Cu induced antitumor activity through MAPK pathway. HGC-27 were exposure to DSF (0.24 μM), DSF + Cu (0.24 μM +0.2 μM) for 24 h. (a) Numbers of up- (red) or down-regulated (blue) genes in HGC-27 cells of different groups. (b) Heatmap showing expression fold change of genes in DSF or DSF/Cu treated cells compared to control group. (c) Pathway enrichment analysis of the differentially expressed genes based on the KEGG database. (d) The mRNA expression of genes involved in the MAPK signaling pathway were measured by RT-qPCR.