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. 2022 Mar 12;13(3):7167–7179. doi: 10.1080/21655979.2022.2034583

Figure 4.

Figure 4.

Reduced HDAC1 or HMGB1 attenuates sepsis in mice. a-d. HMGB1 expression in myocardial tissues of septic mice after down-regulating HMGB1; e. LVEF value in mice with sepsis after down-regulating HMGB1; f. LVFS value of mice with sepsis after down-regulating HMGB1; g. Serum HMGB1 level of mice with sepsis after down-regulating HMGB1; h. Serum BNP level of mice with sepsis after down-regulating HMGB1; i. Serum cTnI level of mice with sepsis after down-regulating HMGB1; j. Serum TNF-α, IL-6 and IL-1β levels of mice with sepsis after down-regulating HMGB1; k. Serum ROS level of mice with sepsis after down-regulating HMGB1; l. SOD activity in myocardial tissues of mice with sepsis after down-regulating HMGB1; m. MDA content in myocardial tissues of mice with sepsis after down-regulating HMGB1; n. GSH-Px in myocardial tissues of mice with sepsis after down-regulating HMGB1; o. HE staining of myocardial tissues of mice with sepsis after down-regulating HMGB1; p. TUNEL staining of myocardial tissues of mice with sepsis after down-regulating HMGB1; q. TNF-α, IL-6, IL-1β, Bcl-2, Bax and Caspase-3 mRNA expression levels in myocardial tissues of mice with sepsis after down-regulating HMGB1; r. cleaved Caspase-3 protein level in myocardial tissues of mice with sepsis after down-regulating HMGB1. The data were all measurement data, and represented by the mean ± standard deviation; # P < 0.05 vs. the sham group; * P < 0.05 vs. the sh-NC group.