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. Author manuscript; available in PMC: 2022 Jul 13.
Published in final edited form as: Nat Struct Mol Biol. 2021 Aug 11;28(8):662–670. doi: 10.1038/s41594-021-00633-2

Extended Data Fig. 10 |. Heterocyclic FLCN-10 peptide induces cell death in ccRCC cells.

Extended Data Fig. 10 |

a) Structural representation of head-to-tail cyclic-FLCN-10 peptide, created using MAESTRO (Schrodinger.com). b) Flow cytometric assessment of cell death in renal cell lines following 1 μM or 10 μM cyclic-FLCN-10 treatment as determined by propidium iodide staining. Representative of three independent experiments. c) Representative flow cytometry gating strategy. Cells were first stratified by size, followed by staining intensity with Annexin V-FITC and Propidium Iodide (Extended Data Fig. 9c, d). The PI intensity signal was converted into a histogram for presentation in Fig. 5a and Extended Data Fig. 10b.