Table 2.
Changes in metabolic parameters for patients with craniopharyngioma after rhGH replacement therapy.
| Metabolic parameter | GHRT group (n = 30) | Control group (n = 12) | Change after one year follow-up | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Before | 1-year GHRT | P | Baseline | 1-year follow-up | P | Change for GHRT group | Change for the control group | P | |
| BMI (kg/m2) | 22.61 ± 5.51 | 22.14 ± 5.23 | 0.217 | 23.78 ± 5.50 | 24.03 ± 5.82 | 0.673 | −0.47 ± 2.05 | 0.25 ± 1.99 | 0.350 |
| BMI z-score | 1.60 ± 1.76 | 1.13 ± 1.73 | 0.005 | 2.23 ± 1.37 | 1.91 ± 1.48 | 0.095 | −0.47 ± 0.84 | −0.32 ± 0.60 | 0.588 |
| Height z-score | −1.98 ± 1.70 | −1.21 ± 1.45 | ≤ 0.001 | −0.66 ± 1.61 | −0.35 ± 1.36 | 0.318 | 0.56 (0.21∼1.37) | 0.31 ± 1.03 | 0.089 |
| IGF-1 (SD) | −2.59 (−2.81∼−2.37) | −1.26 (−1.70∼0.18) | ≤ 0.001 | −2.57 (−2.61∼−1.57) | −1.99 ± 0.56 | 0.182 | 1.36 (1.04∼2.30) | 0.25 ± 0.53 | ≤ 0.001 |
| ALT (U/L) | 26.50 (17.00∼98.00) | 18.00 (13.0∼26.48) | ≤ 0.001 | 26.58 ± 8.75 | 42.58 ± 24.59 | 0.039 | −7.00 (−32.5∼−2.0) | 16.00 ± 23.62 | 0.001 |
| AST (U/L) | 36.00 (28.00∼65.00) | 29.40 (23.00∼35.00) | ≤ 0.001 | 30.00 (27.25∼41.50) | 36.42 ± 9.99 | 0.610 | −7.50 (−43.50∼−9.00) | 1.17 ± 9.71 | 0.007 |
| GGT (U/L) | 22.00 (14.50∼45.00) | 18.50 (12.75∼24.54) | 0.001 | 19.00 (13.25∼29.25) | 25.0 (14.75∼34.75) | 0.026 | −5.00(−20.34∼0.25) | 7.00 (1∼19.5) | ≤ 0.001 |
| TG (mmol/L) | 1.45 (0.71∼2.02) | 1.34 (0.81∼1.83) | 0.551 | 1.52 (0.91∼3.44) | 1.53 ± 0.60 | 0.388 | −0.26 ± 1.40 | −0.33 (−1.03∼0.55) | 0.540 |
| TC (mmol/L) | 4.67 (4.10∼6.14) | 4.32 ± 0.85 | 0.002 | 5.14 ± 1.66 | 4.80 ± 0.74 | 0.417 | −0.65 ± 1.01 | −0.34 ± 1.41 | 0.436 |
| HDL (mmol/L) | 1.06 (0.76∼1.42) | 1.12 ± 0.33 | 0.574 | 0.95 ± 0.27 | 1.06 ± 0.28 | 0.073 | 0.02 ± 0.40 | 0.10 ± 0.18 | 0.513 |
| LDL (mmol/L) | 3.05 ± 0.95 | 2.56 ± 0.65 | 0.001 | 2.27 ± 0.76 | 3.43 ± 1.28 | 0.040 | −0.49 ± 0.72 | 0.74 ± 1.10 | ≤0.001 |
| FBG (mmol/L) | 4.72 ± 0.73 | 4.77 ± 0.38 | 0.635 | 4.87 ± 0.49 | 4.92 ± 0.49 | 0.631 | 0.06 ± 0.66 | 0.05 ± 0.35 | 0.971 |
| BUN (mmol/L) | 4.53 ± 1.09 | 3.92 ± 0.82 | 0.016 | 3.90 ± 0.86 | 3.94 ± 0.82 | 0.900 | −0.61 ± 1.30 | 0.04 ± 1.10 | 0.137 |
| SCr (µmol/L) | 55.59 ± 12.54 | 51.15 ± 10.51 | 0.005 | 51.25 ± 19.08 | 53.92 ± 13.66 | 0.584 | −4.43 ± 8.06 | 5.00 (4.00∼15.0) | 0.004 |
| Che (KU/L) | 10.39 ± 2.16 | 10.6 (9.7∼11.8) | 0.136 | 9.97 ± 1.05 | 10.04 ± 1.14 | 0.627 | 0.39 ± 1.94 | 0.16 ± 1.13 | 0.707 |
| LDH (U/L) | 281.14 ± 43.03 | 250.23 ± 32.85 | ≤ 0.001 | 278.00 ± 53.16 | 269.73 ± 50.26 | 0.524 | −31.21 ± 40.71 | −8.27 ± 43.59 | 0.114 |
| hsCRP (mg/L) | 3.23 (1.79∼4.34) | 0.92 (0.42∼1.21) | ≤ 0.001 | 1.83 (0.79 ± 2.52) | 2.26 (0.63∼3.91) | 0.117 | −1.93 (−2.47∼−0.97) | 0.64 (−0.28∼1.99) | ≤ 0.001 |