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Evaluation of the cytotoxicity of the different formulations after 48 h incubation with MDA-MB-468 cell line. (a) Cytotoxicity comparison between DOX, SLNs/DOX, and DOX-SLNs-Dexa. (b) Cytotoxicity comparison between SLNs/DOX/Dexa with SLNs/DOX/Dexa/EGFR, SLN/Dox/Dexa/CD44, and SLNs/DOX/Dexa/CD44/EGFR. SLNs/DOX/Dexa/CD44/EGFR are substantially more effective in reducing the cell line viability (n = 3, ∗p < 0.05, ∗∗p < 0.01, and ∗∗∗p < 0.001).
