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. 2022 Jun 20;54(7):985–995. doi: 10.1038/s41588-022-01088-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — (a) Expression of intestinal stem cell and colon cancer stem cell marker genes in stem cells, TA2 cells, TA1 cells, and Enterocytes by sample. Samples are ordered by the malignancy continuum defined in Fig. 4. (B, c) Heatmaps of all peaks that were significantly differentially accessible (Wilcoxon test, padj≤0.05 & |log2FC | ≥1.5) in ≥2 samples. Samples are ordered along the x-axis by the malignancy continuum defined in Fig. 4. Peaks are k-means clustered into 5 (b) or 15 (c) clusters. (d, e) Hypergeometric enrichment of TF motifs in k-means clusters of peaks defined in B (d) and C (e). (f) Heatmap of all peaks that were significantly differentially accessible in ≥2 samples between stem cells from a given sample and normal colon stem cells. Samples are ordered along the x-axis by the malignancy continuum defined in Fig. 4. Peaks are k-means clustered into 10 groups. (g) Hypergeometric enrichment of TF motifs in k-means clusters of peaks defined in F. (h) Heatmap representation of cell types in each epithelial sample as determined by the nearest normal cell after projecting the cells into the normal LSI subspace.