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. 2022 Jun 20;54(7):985–995. doi: 10.1038/s41588-022-01088-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 9 — (a–c) Accessibility tracks around BMP3 (a), GRASP (b), and CIDEB (c), which are hypermethylated in CRC. (d) Adjusted p-value and mean difference in β-value cutoffs used to determine differentially methylated probes. P values were determined using the two-sided Wilcoxon test and were adjusted with the Benjamini-Hochberg method for multiple hypothesis testing. (e) Genes that were significantly differential along the malignancy continuum that also have differentially methylated probes within 500 bp of their TSS in TCGA 450 K methylation data. Genes are grouped into a heatmap of those with hypermethylated probes in their promoters and a heatmap of those with hypomethylated probes in their promoters.