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. 2022 Jun 20;54(7):985–995. doi: 10.1038/s41588-022-01088-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–h, Fraction of cell type in each scATAC sample plotted against position of the sample in the malignancy continuum defined in Fig. 4d for stem-like cells (a), enterocytes (b), immature goblet cells (c), goblet cells (d), Tregs (e), exhausted T cells (f), preCAFs (g) and CAFs (h). Samples are colored based on if they are derived from unaffected tissues, polyps or CRCs. Fractions are computed by dividing the number of cells of a given cell type by the total number of cells in the compartment (epithelial versus immune versus stromal). i, Stacked boxplot representation of the fraction of epithelial cells of each cell type for each scATAC sample along the malignancy continuum.