Extended Data Table 1.
Selection peaks
| Chr | Start (Mb) | End (Mb) | Description and notes on genes within region |
|---|---|---|---|
| 1 | 103.7 | 103.8 | ZNF331, zinc-finger protein involved in transcriptional regulation |
| 2 | 6.77 | 6.84 | YME1L1 involved in mitchondrial morphology, highly expressed in muscle. Mutations in humans associated with optic atrophy |
| 3 | 72.35 | 72.45 | N4BP2 may play a role in DNA repair or recombination |
| 4 | 32.22 | 32.25 | No genes |
| 6 | 9.85 | 9.95 | CYP3A26 is a cytochrome P450 enzyme |
| 6 | 13.85 | 14.05 | No genes |
| 6 | 43.8 | 43.82 | VAV3 involved in angiogenesis |
| 7 | 29 | 29.05 | F5 is coagulation factor V, SELL has immunity function |
| 9 | 2.2 | 2.3 | No genes, lncRNA |
| 9 | 8.95 | 9.6 | KANSL1 associated to Koolen-de Vries hypersociability syndrome, MYL4 is involved in muscle function |
| 10 | 7.62 | 7.7 | Dog QTL locus associated to drop ears, body mass and other traits. WIF1 inhibits Wnt signalling, role in embryonic development |
| 10 | 7.95 | 8.09 | Dog QTL locus associated to drop ears, body mass and other traits. Human mutations in MSRB3 associated to deafness |
| 10 | 8.14 | 8.24 | Dog QTL locus associated to drop ears, body mass and other traits. |
| 11 | 0.75 | 1.15 | OR2AI2 is olfactory receptor, IFGGB2 has immunity function |
| 11 | 56.72 | 56.77 | No genes |
| 15 | 0.1 | 0.5 | Olfactory gene cluster, SLC2A1 is Glucose transporter 1 |
| 15 | 3.92 | 3.98 | No genes |
| 15 | 6.53 | 6.57 | TFAP2E linked to Branchiooculofacial Syndrome which includes facial development problems |
| 15 | 13.5 | 13.7 | Three cytochrome P450 enzyme genes, involved in lipid and secondary metabolism |
| 21 | 28.02 | 28.07 | Olfactory gene cluster |
| 22 | 2.8 | 2.92 | lncRNA, just downstream of CYSLTR2 |
| 25 | 17.4 | 17.56 | IFT88, involved in craniofacial development |
| 25 | 19.77 | 19.9 | Uncharacterized gene |
| 30 | 2.69 | 2.75 | No genes |
Locations in the genome of regions displaying evidence of natural selection across the wolf time series, with comments on any genes within the region. For a more detailed table see Supplementary Data 3.