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. 2022 Jun 30;54(7):963–975. doi: 10.1038/s41588-022-01100-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — Proportion of mutation types and locations in a. KRAS (n = 206) and b. NRAS (n = 27) in samples with KRAS/NRAS mutations from TCGA and SG-Bulk data; number of samples in each group is labelled. Comparisons are between iCMS2/iCMS3 (top), and iCMS2_MSS/iCMS3_MSS/iCMS3_MSI (bottom). c. Scaled gene expression of selected MAPK pathway genes in iCMS2 (n = 396) and iCMS3 (n = 312), from TCGA and SG-Bulk datasets. P-values shown are by two-sided Wilcoxon rank-sum test without correction. d. Mutational landscape of selected TGF-beta pathway genes in iCMS2 (top, n = 344) and iCMS3 (bottom, n = 281) samples in TCGA and SG-Bulk datasets. e. Scaled gene expression of selected TGF-beta pathway genes iCMS2 (n = 396) and iCMS3 (n = 312) (left) and across the IMF 5 categories: i2_MSS (n = 240), i2_fibrotic (n = 82), i3_MSS (n = 92), i3_fibrotic (n = 58), i3_MSI (n = 105) (right). P-values are calculated using two-sided Wilcoxon rank-sum test without correction.