Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Jun 30;54(7):963–975. doi: 10.1038/s41588-022-01100-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 7 — a,b, Heatmaps of tubular adenoma (AD) (a) and SSL (b) marker genes obtained from Chen et al. ⁴⁴, colored by the average of scaled (z-transformed) expression values of epithelial single cells from five-cohort scRNA-seq data (patients = 61). c, Barplots quantify enrichment of tissue-specific genes in each of the four DEG sets, calculated using the TissueEnrich package (iCMS2 Up: 308; iCMS2 Down: 279; iCMS3 Up: 74; iCMS3 down: 54; total: 715). Red line, P = 0.1. The heatmaps show expression levels of the seven iCMS3-Up DEGs defined as stomach-specific in the TissueEnrich database. Left, scaled expression in diverse tissues. Right, scaled epithelial pseudo-bulk expression in 61 patients. d, Heatmap of gastric metaplasia signature genes, similar to a and b. e, Heatmap of GSEA leading edge genes within crypt top and crypt bottom gene sets, showing scaled epithelial pseudo-bulk expression levels across 61 patients from five scRNA-seq cohorts.