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. 2022 Feb 7;61(5):2397–2416. doi: 10.1007/s00394-022-02805-2

Table 2.

Hazard ratios and 95% confidence intervals for BC according to dietary B group vitamin intake in the BLEND study

Overall (n = 532,927) Men (n = 171,771) Women (n = 361,156)
Low Moderate High P Low Moderate High P Low Moderate High p
Thiamin (B1)
 Model 1a 1

1.10

(1.00–1.20)

1.04

(0.95–1.14)

  < 0.001 1

1.13

(1.02–1.26)

1.13

(1.02–1.26)

  < 0.001 1

1.03

(0.87–1.22)

0.80

(0.67–0.97)

  < 0.001
 Model 2b 1

1.14

(1.03–1.26)

1.14

(1.01–1.29)

  < 0.001 1

1.16

(1.03–1.30)

1.20

(1.05–1.38)

  < 0.001 1

1.13

(0.94–1.36)

0.96

(0.75–1.23)

  < 0.001
Riboflavin (B2)
 Model 1a 1

1.07

(0.98–1.17)

0.99

(0.91–1.08)

  < 0.001 1

1.14

(1.02–1.26)

1.06

(0.95–1.17)

  < 0.001 1

0.91

(0.76–1.08)

0.83

(0.70–1.00)

  < 0.001
 Model 2b 1

1.10

(1.00–1.21)

1.06

(0.93–1.21)

  < 0.001 1

1.14

(1.02–1.28)

1.06

(0.91–1.23)

  < 0.001 1

1.01

(0.83–1.22)

1.04

(0.80–1.35)

  < 0.001
Niacin (B3)
 Model 1a 1

1.02

(0.93–1.12)

0.98

(0.90–1.07)

  < 0.001 1

1.05

(0.94–1.17)

1.06

(0.95–1.18)

  < 0.001 1

0.97

(0.82–1.15)

0.77

(0.63–0.93)

  < 0.001
 Model 2b 1

1.03

(0.94–1.14)

1.02

(0.91–1.14)

  < 0.001 1

1.05

(0.94–1.18)

1.07

(0.94–1.21)

  < 0.001 1

1.03

(0.86–1.24)

0.87

(0.68–1.10)

  < 0.001
Pyridoxine (B6)
 Model 1a 1

1.00

(0.92–1.09)

0.95

(0.87–1.04)

  < 0.001 1

1.05

(0.95–1.17)

1.05

(0.94–1.16)

  < 0.001 1

0.89

(0.75–1.06)

0.73

(0.61–0.88)

  < 0.001
 Model 2b 1

1.01

(0.92–1.12)

0.99

(0.86–1.13)

  < 0.001 1

1.06

(0.94–1.19)

1.06

(0.91–1.25)

  < 0.001 1

0.92

(0.75–1.12)

0.79

(0.59–1.04)

  < 0.001
Folate (B9)
 Model 1a 1

1.04

(0.95–1.14)

0.99

(0.90–1.08)

  < 0.001 1

1.09

(0.98–1.21)

1.05

(0.95–1.17)

  < 0.001 1

0.93

(0.79–1.11)

0.82

(0.68–0.99)

  < 0.001
 Model 2b 1

1.06

(0.96–1.16)

1.03

(0.93–1.14)

  < 0.001 1

1.09

(0.98–1.22)

1.06

(0.94–1.20)

  < 0.001 1

0.99

(0.83–1.19)

0.93

(0.75–1.16)

  < 0.001
Cyanocobalamin (B12)
 Model 1a 1

0.97

(0.89–1.05)

0.94

(0.85–1.03)

  < 0.001 1

0.96

(0.87–1.06)

1.01

(0.91–1.13)

  < 0.001 1

0.99

(0.83–1.18)

0.79

(0.66–0.95)

  < 0.001
 Model 2b 1

0.97

(0.89–1.07)

0.95

(0.85–1.06)

  < 0.001 1

0.95

(0.86–1.06)

1.00

(0.88–1.13)

  < 0.001 1

1.04

(0.87–1.25)

0.88

(0.71–1.08)

  < 0.001
Energy metabolism (B1*B2*B3)
 Model 1a 1

1.07

(0.98–1.17)

1.01

(0.92–1.10)

  < 0.001 1

1.13

(1.02–1.26)

1.09

(0.98–1.21)

  < 0.001 1

0.94

(0.79–1.12)

0.80

(0.66–0.96)

  < 0.001
 Model 2b 1

1.10

(1.00–1.22)

1.08

(0.96–1.23)

  < 0.001 1

1.15

(1.02–1.28)

1.13

(0.98–1.30)

  < 0.001 1

1.02

(0.84–1.24)

0.94

(0.73–1.21)

  < 0.001
Oxidative stress reduction (B2*B6)
 Model 1a 1

1.02

(0.93–1.11)

0.96

(0.88–1.05)

  < 0.001 1

1.08

(0.97–1.20)

1.05

(0.95–1.17)

  < 0.001 1

0.89

(0.74–1.05)

0.74

(0.62–0.89)

  < 0.001
 Model 2b 1

1.04

(0.94–1.15)

1.01

(0.87–1.16)

  < 0.001 1

1.08

(0.97–1.22)

1.08

(0.92–1.26)

  < 0.001 1

0.92

(0.75–1.13)

0.80

(0.60–1.07)

  < 0.001
DNA stability (B9*B12)
 Model 1a 1

1.00

(0.92–1.10)

0.95

(0.87–1.05)

  < 0.001 1

1.01

(0.91–1.12)

1.04

(0.94–1.16)

  < 0.001 1

0.99

(0.84–1.18)

0.76

(0.63–0.92)

  < 0.001
 Model 2b 1

1.02

(0.93–1.12)

0.99

(0.88–1.11)

  < 0.001 1

1.02

(0.91–1.13)

1.06

(0.92–1.21)

  < 0.001 1

1.04

(0.86–1.24)

0.84

(0.67–1.06)

  < 0.001
Vitamin B complex (B1*B2*B3*B6*B9*B12)
 Model 1a 1

1.06

(0.97–1.15)

0.93

(0.84–1.03)

  < 0.001 1

1.07

(0.97–1.18)

0.94

(0.84–1.06)

  < 0.001 1

1.03

(0.86–1.24)

0.93

(0.77–1.11)

  < 0.001
 Model 2b 1

1.05

(0.96–1.14)

0.91

(0.82–1.01)

  < 0.001 1

0.97

(0.97–1.18)

0.94

(0.83–1.06)

  < 0.001 1

1.01

(0.84–1.20)

0.91

(0.76–1.09)

  < 0.001

BC Bladder Cancer, BLEND BLadder cancer Epidemiology and Nutritional Determinants

aAdjusted for sex, age, and smoking status

bAdjusted for sex, age, smoking status and water