Table 5.
Hazard ratios and 95% confidence intervals for NMIBC according to dietary B group vitamin intake in the BLEND study
| Overall (n = 532,271) | Men (n = 171,249) | Women (n = 361,022) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Low | Moderate | High | P | Low | Moderate | High | P | Low | Moderate | High | p | |
| Thiamin (B1) | ||||||||||||
| Model 11 | 1 |
1.06 (0.95–1.17) |
1.02 (0.92–1.13) |
< 0.001 | 1 |
1.09 (0.96–1.23) |
1.10 (0.98–1.24) |
< 0.001 | 1 |
1.00 (0.83–1.21) |
0.79 (0.64–0.97) |
< 0.001 |
| Model 22 | 1 |
1.10 (0.99–1.23) |
1.12 (0.98–1.28) |
< 0.001 | 1 |
1.11 (0.97–1.26) |
1.17 (1.00–1.37) |
< 0.001 | 1 |
1.11 (0.91–1.37) |
0.98 (0.74–1.28) |
< 0.001 |
| Riboflavin (B2) | ||||||||||||
| Model 11 | 1 |
1.03 (0.93–1.14) |
0.96 (0.86–1.06) |
< 0.001 | 1 |
1.09 (0.96–1.23) |
1.02 (0.91–1.15) |
< 0.001 | 1 |
0.89 (0.74–1.08) |
0.80 (0.65–0.98) |
< 0.001 |
| Model 22 | 1 |
1.05 (0.94–1.18) |
1.01 (0.88–1.17) |
< 0.001 | 1 |
1.08 (0.95–1.23) |
1.01 (0.85–1.20) |
< 0.001 | 1 |
1.00 (0.81–1.24) |
1.02 (0.76–1.36) |
< 0.001 |
| Niacin (B3) | ||||||||||||
| Model 11 | 1 |
0.97 (0.87–1.07) |
0.95 (0.86–1.05) |
< 0.001 | 1 |
0.99 (0.87–1.12) |
1.03 (0.92–1.16) |
< 0.001 | 1 |
0.94 (0.78–1.13) |
0.73 (0.59–0.90) |
< 0.001 |
| Model 22 | 1 |
0.98 (0.88–1.10) |
0.99 (0.87–1.13) |
< 0.001 | 1 |
0.99 (0.87–1.13) |
1.04 (0.90–1.21) |
< 0.001 | 1 |
1.00 (0.82–1.22) |
0.83 (0.64–1.08) |
< 0.001 |
| Pyridoxine (B6) | ||||||||||||
| Model 11 | 1 |
0.95 (0.85–1.05) |
0.91 (0.82–1.00) |
< 0.001 | 1 |
0.97 (0.86–1.09) |
1.00 (0.89–1.12) |
< 0.001 | 1 |
0.89 (0.74–1.08) |
0.69 (0.56–0.84) |
< 0.001 |
| Model 22 | 1 |
0.95 (0.85–1.06) |
0.91 (0.78–1.07) |
< 0.001 | 1 |
0.96 (0.84–1.10) |
0.98 (0.81–1.18) |
< 0.001 | 1 |
0.92 (0.74–1.15) |
0.74 (0.54–1.01) |
< 0.001 |
| Folate (B9) | ||||||||||||
| Model 11 | 1 |
1.02 (0.92–1.13) |
0.97 (0.88–1.08) |
< 0.001 | 1 |
1.07 (0.95–1.21) |
1.04 (0.92–1.17) |
< 0.001 | 1 |
0.90 (0.75–1.09) |
0.79 (0.64–0.98) |
< 0.001 |
| Model 22 | 1 |
1.04 (0.93–1.16) |
1.02 (0.91–1.15) |
< 0.001 | 1 |
1.08 (0.95–1.22) |
1.06 (0.92–1.21) |
< 0.001 | 1 |
0.97 (0.79–1.18) |
0.91 (0.71–1.15) |
< 0.001 |
| Cyanocobalamin (B12) | ||||||||||||
| Model 11 | 1 |
0.91 (0.83–1.00) |
0.94 (0.84–1.04) |
< 0.001 | 1 |
0.89 (0.80–1.00) |
1.01 (0.89–1.15) |
< 0.001 | 1 |
0.98 (0.80–1.19) |
0.80 (0.65–0.97) |
< 0.001 |
| Model 22 | 1 |
0.92 (0.83–1.02) |
0.96 (0.85–1.09) |
< 0.001 | 1 |
0.88 (0.79–1.00) |
1.00 (0.86–1.15) |
< 0.001 | 1 |
1.03 (0.84–1.26) |
0.91 (0.72–1.15) |
< 0.001 |
| Energy metabolism (B1*B2*B3) | ||||||||||||
| Model 11 | 1 |
1.04 (0.93–1.15) |
0.98 (0.88–1.08) |
< 0.001 | 1 |
1.09 (0.97–1.23) |
1.06 (0.94–1.19) |
< 0.001 | 1 |
0.92 (0.76–1.11) |
0.77 (0.62–0.94) |
< 0.001 |
| Model 22 | 1 |
1.07 (0.96–1.19) |
1.05 (0.91–1.20) |
< 0.001 | 1 |
1.10 (0.97–1.25) |
1.09 (0.93–1.28) |
< 0.001 | 1 |
1.01 (0.82–1.25) |
0.93 (0.70–1.23) |
< 0.001 |
| Oxidative stress reduction (B2*B6) | ||||||||||||
| Model 11 | 1 |
0.98 (0.89–1.09) |
0.91 (0.83–1.01) |
< 0.001 | 1 |
1.04 (0.92–1.17) |
1.00 (0.89–1.13) |
< 0.001 | 1 |
0.87 (0.72–1.05) |
0.69 (0.57–0.85) |
< 0.001 |
| Model 22 | 1 |
0.99 (0.88–1.11) |
0.92 (0.79–1.08) |
< 0.001 | 1 |
1.03 (0.90–1.17) |
0.98 (0.82–1.18) |
< 0.001 | 1 |
0.91 (0.72–1.13) |
0.75 (0.55–1.03) |
< 0.001 |
| DNA stability (B9*B12) | ||||||||||||
| Model 11 | 1 |
0.98 (0.89–1.08) |
0.95 (0.85–1.05) |
< 0.001 | 1 |
0.98 (0.87–1.10) |
1.02 (0.90–1.16) |
< 0.001 | 1 |
0.99 (0.82–1.20) |
0.77 (0.63–0.95) |
< 0.001 |
| Model 22 | 1 |
1.00 (0.90–1.11) |
0.99 (0.87–1.13) |
< 0.001 | 1 |
0.98 (0.87–1.11) |
1.04 (0.89–1.21) |
< 0.001 | 1 |
1.05 (0.86–1.28) |
0.88 (0.69–1.14) |
< 0.001 |
| Vitamin B complex (B1*B2*B3*B6*B9*B12) | ||||||||||||
| Model 11 | 1 |
1.01 (0.92–1.11) |
0.92 (0.83–1.03) |
< 0.001 | 1 |
1.03 (0.92–1.15) |
0.93 (0.81–1.07) |
< 0.001 | 1 |
0.95 (0.78–1.16) |
0.90 (0.74–1.10) |
< 0.001 |
| Model 22 | 1 |
0.99 (0.90–1.10) |
0.90 (0.81–1.01) |
< 0.001 | 1 |
1.03 (0.92–1.15) |
0.92 (0.80–1.06) |
< 0.001 | 1 |
0.93 (0.76–1.14) |
0.91 (0.74–1.11) |
< 0.001 |
NMIBC Non-Muscle Invasive Bladder Cancer, BLEND BLadder cancer Epidemiology and Nutritional Determinants
1Adjusted for sex, age, and smoking status
2Adjusted for sex, age, smoking status and water