Table 4.

Diagnostic performance of CTA and Agatston score on the patient level*

	CTA n/total n (% [95% CI*])	Agatston score§ n/total n (% [95% CI*])	p-value*
Diagnostic accuracy	1942/2452 (81.1% [77.5 – 84.1])	1639/2452 (68.8% [64.2–73.1])	< 0.0001
Sensitivity	943/1100 (86.4% [83.7 – 88.7])	443/1100 (40.9% [36.6–45.3])	< 0.0001
Specificity	999/1352 (73.2% [69.5 – 76.6])	1196/1352 (88.2% [85.8–90.2])	< 0.0001
Negative predictive value	999/1156 (85.2% [81.3 – 88.3])	1196/1853 (64.1% [58.4–69.4])	< 0.0001
Positive predictive value	943/1296 (73.1% [67.9 – 77.8])	443/599 (75.8% [70.2–80.7])	0.2206
Positive likelihood ratio	3.54 [2.61–4.81]	3.10 [2.37–4.06]
Negative likelihood ratio	0.14 [0.09–0.23]	0.67 [0.60–0.75]
DOR	31.42 [13.68–72.14]	5.40 [3.60–8.09]

*CI, confidence interval. Estimates, 95% CI, and p-values are based on a model with study-specific random intercept taking test correlation within patients into account. ^§An Agatston score above 400 was considered positive

Positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio (DOR) based on random effect models for each test