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. 2022 Jul 12;8:317. doi: 10.1038/s41420-022-01105-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Trp53 expression was identified in the primary chondrocytes using the publicly available early murine limb development data from GSE30138 [29] as indicated. E: embryonic day. B Representative immunofluorescent image of Trp53 in the tibia from wild-type mice as shown. P0: the newborn. Scale bars, 75 μm. C Trp53 expression in cartilage as indicated. P: postnatal day. D, E Trp53 expression was determined by qRT-PCR and western blot after culture as indicated time in chondrogenic differentiation medium. D: day. *P < 0.05, **P < 0.01, ***P < 0.001.