Figure 4.

Glycine mutations at the internal docking site disturb the E-S interaction. (A) Top-view at the PS1 internal docking site of C99_V44G (left), C99_I45G (middle), and C99_GG bound γ-secretase complexes (representation same as in Fig. 2C). (B) Probability density of the catalytic hydrogen bond distance during simulations. (C) RMSF of the substrate TMD and (D) residue-wise water accessibility of C99_wt (black), C99_V44G (orange), C99_I45G (blue), and C99_GG (brown) during simulations in complex with γ-secretase. To see this figure in color, go online.