Figure 7.

Influence of the APP mutations G33I and K28A on the Aβ40_γ37 binding pose. (A) Probability density of the catalytic hydrogen bond distance. (B) Top-view at the PS1 internal docking site of Aβ40_γ37,G33I-bound (left) and Aβ40_γ37,K28A-bound (right) γ-secretase complexes. Atomic representation is the same as in Fig. 2C. (C) Distribution of the membrane-anchoring residue K28 (middle) and substrate P6 (right) along the z axis. (D) Average z axis of the POPC phosphate on the extracellular side distributed along the radial distance ρ_xy,K/A28. To see this figure in color, go online.