Figure 11.

(a) Key structural features of CyclinD/Cdk4/p27 complex. (b) The distance between amino-acid residue 74 of the three Cip/Kip inhibitors in different states of phosphorylation, and the center of mass of Cdk4. As the dislocation of residue 74 from the complex is known to lead to activation of Cdk4, we show that this as an indicator of potential activity. (c) The distance between the catalytic lysine in Cdk4 and the center of mass of the Cdk4 C helix. To see this figure in color, go online.