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Solvent-accessible surface area of three tyrosine residues of interest: (a) tyrosine Y88 in p27, which is positioned within the active-site pocket, and the equivalent tyrosine position in p57 and p21 (position Y91 and Y77 respectively); (b) p27 position Y89, positioned within the Cdk2 active site pocket but only present in p27; and (c) distal from the active site, p27 Y74, and near-equivalent site Y63 in p57. To see this figure in color, go online.
