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. 2022 Jul 13;13:4069. doi: 10.1038/s41467-022-31770-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 10 — a Box plot indicating the relative frequency of cell–cell interactions among human, monkey and mouse. Each point denotes a specific intercellular interaction in a specific organ. The number of significant cell–cell interactions are scaled to a range from 0 and 1 for inter-species comparison. b Scatter plots show the Spearman’s rank correlation of cell–cell interaction frequencies between human and monkey (left) or between human and mouse (right). P-values are provided (two-sided Spearman’s correlation test). The fitted line and standard errors with 95% confidence intervals are shown. c The heatmaps showing the strength of interactions among the common major cell types in kidney and spleen in the three species. The size and color of the blocks are proportional to the frequency of interactions. P-values were calculated by CellPhoneDB without multiple comparisons. d Dot plot of interactions between major cell subtypes in kidneys and spleens of different species. Each row represents a ligand-receptor pair, and each column defines a cell–cell interaction pair in a species.