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. 2022 Jul 13;13:4005. doi: 10.1038/s41467-022-30458-6

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© This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply 2022

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Fig. 1 — a 2D cryo-EM images of aRML fibrils. Bar = 50 nm. Inset depicts associated Fast Fourier transform showing signals from regular 4.9 Å spacings (yellow arrows). The white arrowhead indicates a rare example of aRML fibrils that appear to be paired. Micrographs shown are representative of 2272 movies collected for subsequent image processing and single particle analysis (see the “Methods” section). b Cross-sectional view of a density map projection. c Lateral view of the fibril density map with cross-over distance as indicated. d Core sequence showing relative orientations of side chains. Green, polar; blue, basic; red, acidic; white, aliphatic; gray, aromatic; pink—glycine. e Coulombic charge representation. f MLP hydrophobicity surface plot demonstrating interspersed hydrophobic interactions.