Figure 3.

T cell interaction as a means of B cell maturation in the synovial tissue. (A) Expression of genes associated with antigen presentation and costimulation are displayed on the three major clusters formed from the single B cell RNAseq. (B) Upon factor analyses, four B cell factors and one T-B cell interaction factor are shown with factor activities. These signatures overlap in distinct morphological areas of both ACPA− and ACPA+ tissue sections. (C) Pathway analysis from the top-20 genes for B cell and (D) T-B cell interaction factors (T cell factor) in B showed BCR signaling and PD-1 signaling, respectively.