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. 2022 Jul 13;12:11876. doi: 10.1038/s41598-022-15293-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Clonotype characterization of synovial plasma cell derived antibodies. (A) We show clonotypes for five plasma cell derived monoclonal antibodies from A2. Each clonotype is defined by identical heavy and light chain V and J gene usage (grey boxes). Each clone with a unique sequence for the combination of heavy and light chain is assigned a number (y-axis). This sequence is described by the SHM and the complementary determining region 3 (CDR3) for the heavy and light chain in the table below. The x-axis and dot color depict the memory B (mem) or plasma cell (PC) cluster identity of the clone members by transcriptomic profile. It additionally defines the heavy chain isotype of the clone members in the order of possible class switch recombination from left to right. NA means not available from the data. The area of the dots is proportional to the number of identified members; e.g. the largest area within the first clone is equivalent to 16 members while the smallest area is equivalent to 1 member. (B) The plot shows the equivalent clonotype information that is shown in panel (A) for the two plasma cell derived monoclonal antibodies from A3.