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. 2022 Jul 13;12:11876. doi: 10.1038/s41598-022-15293-5

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© The Author(s) 2022

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Reactivity landscape of synovial plasma cell derived antibodies. (A) Phylogenic tree of the B cell receptor clones of one of the ACPA positive individuals (A2). Clonotypes from figure are highlighted. (B) One of the monoclonal antibodies (dark purple) was identified as an anti-citrullinated protein antibody (ACPA) based on being CCP positive (upper panel), but not polyreactive (lower panel). Several antibodies showed polyreactivity. *Indicates insertion of N-linked glycosylation sites by SHM. (C) The A4802:3286 ACPA has strong reactivity towards mutated citrullinated vimentin peptide. (D) Vimentin is expressed within the corresponding tissue analyzed by spatial transcriptomics. (E) The A4802:3286 ACPA derives from two identical IgD− CD27++ plasma cells.