Table 1.
Patient characteristics.
| All (n = 8) | ACPA+ | ACPA+ | ACPA− | ACPA− | |
|---|---|---|---|---|---|
| Subjects (N/gender) | 7 F/1 M | F | F | F | F |
| Age (median/range) | 70 (23–80) | 70–75 | 45–50 | 70–75 | 60–65 |
| CCP-titer (range/cut-off 3) |
4 + (80–300) 4 − (< 0.5–0.5) |
300 | > 300 | < 0.5 | 0.5 |
| RF status (+/−) | 4+/4− | + | + | − | − |
| Tender joints, 28-count (median, range) | 11 (8–16) | 10 | 8 | 16 | 8 |
| Swollen joints, 28-count (median, range) | 10 (1–18) | 16 | 7 | 14 | 11 |
| Pain, global VAS (median, range) | 75 (26–87) | 87 | 50 | 84 | 83 |
| CRP, mg/l (median, range) | 14 (1–135) | 81 | 4 | 14 | 135 |
| ESR, mm (median, range) | 49 (20–71) | 44 | 36 | 56 | 71 |
| DAS28-CRP (median, range) | 5.4 (3.85–6.66) | 6.66 | 4.56 | 6.4 | 6.4 |
| DAS28-SR (median, range) | 6.47 (5.07–7.28) | 6.76 | 5.53 | 7.28 | 6.66 |
| Time of biopsy (days after diagnosis) | 2 (1–2) | 2 | 2 | 2 | 2 |
| Time of symptom (months before diagnosis) | 6 (2–24) | 24* | 5.5 | 4 | 5 |
*This patient had knee pain 24 months prior to fulfilling an RA diagnosis that was ascribed as early knee arthrosis based on X-ray (no any alterations in small joints were found at this time point). She subsequently developed small joint arthritis 1 month prior to RA diagnosis.