Figure 1.

SARS-CoV-2 variation in the immunodominant YLQPRTFLL dominant HLA A^∗02-restricted CD8 T cell epitope

(A) Cumulative frequency of all sequences; sequences in the B.1.177 lineage; and sequences possessing the P272L variant across the United Kingdom (left) and worldwide (right). See Figure S1 for the total number of P272L variants by nation, binned into periods of 16 epidemiological (EPI) weeks is shown.

(B) Top 15 most frequently observed variants observed in worldwide Spike glycoprotein sequence data in lineage B.1.177 as a percentage of total sequences. Data for all lineages are shown in Table S1.

(C) Phylogenetic tree showing 1,227 taxa with variants at Spike position 272, with colors indicating subtrees representing potential independent mutations, computed by ASR on a larger tree of 200,221 taxa (not shown).

(D) Percentage of sequences possessing P272L variant in England and Wales per administrative region up to and including January 1^st, 2022.

See also Figures S1 and S2.