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. 2022 Jul 13;13:4061. doi: 10.1038/s41467-022-31574-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a,b Kaplan–Meier estimates of nude mice orthotopically engrafted with stably HHIP-AS1-silenced (sh-HHIP-AS1#1) Daoy (a, n = 13 mice) and CHLA-266 (b, n = 13 mice) cells compared to corresponding controls (sh-scr), respectively. c Survival curves of nude mice orthotopically engrafted with transiently HHIP-AS1-silenced (sh-HHIP-AS1#1) SHH-Med-1712-FH cells (n = 17mice). For panels a, b, and c, the median survivals were compared using Mantel–Cox test. d,e Three controls and three HHIP-AS1-depleted SHH-Med-1712-FH tumors were immunostained for Ki67 (yellow, d, white scale bar: 100 µm), γH2AX (red, e, white scale bar: 40 µm) and the percentage of positive stained tumor cells is plotted in the bar graphs as mean ± SD. Nuclei are stained with DAPI (blue). Both, control (ctrl = sh-scr) and sh-HHIP-AS1#1 tumor tissue, are shown in the two representative images. Student’s two-sided t-test, **p < 0.01. Source data and exact p-values are provided as a “Source Data file”.