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EV-A71 capsid inhibitors targeting the VP1 hydrophobic pocket. (A) Cryo-EM structure of EV-A71 capsid proteins in complex with sphingosine (PDB: 6UH6) and (B) NLD-22 (PDB: 6LQD). VP1, VP2, VP3, and NLD-22 were colored in gray, tint, yellow, and magenta, respectively. (C) Chemical structures of EV-A71 capsid inhibitors targeting the VP1 hydrophobic pocket.
