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EV-A71 2C inhibitors. (A) X-ray crystal structure of EV-A71 2C protein (PDB: 5GRB). One monomer is colored in cyan, and another monomer is colored in gray and shown in surface. ATP is shown in sticks. (B) X-ray crystal structure of CV-B3 2C (117-329) in complex with (S)-fluoxetine (PDB: 6T3W). (C) Cryo-electron micrographs of CV-B3 2C with (S)-fluoxetine (SFX) and ATP. Reprinted from Ref. 132. (D) Chemical structure of EV-A71 2C inhibitors.
