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EV-A71 3C inhibitors. (A) Chemical structures of EV-A71 3Cpro inhibitors. (B) X-ray crystal structure of EV-A71 3Cpro in complex with rupintrivir (AG7088) (PDB: 3SJO). (C) X-ray crystal structure of EV-A71 3Cpro in complex with 3C-18p (PDB: 7DNC). Reprinted with permission from Ref. 157. Copyright © 2021, American Chemical Society. (D) X-ray crystal structure of EV-A71 3Cpro in complex with macrocyclic inhibitor 3C-4 (PDB: 6LKA).
