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. 2022 Jun 15;26(14):3977–3994. doi: 10.1111/jcmm.17434

FIGURE 8.

FIGURE 8

Expression profiles of senescence markers. The expression profiles of a panel of genes involved in the maintenance of telomeric integrity and/or associated with differentiation and senescence in keratinocyte stem cells were obtained from Limbal Holoclone cultures either untreated (LH) or treated with DAPT (LH‐DAPT) by means of RNAseq analysis. Normalized expression of the indicated markers is plotted against the culture passage. The time series relative to LH and LH‐DAPT is compared using an analysis of covariance test (p < .05). LH, limbal holoclones