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. 2021 Nov 16;12(4):2120–2126. doi: 10.1016/j.apsb.2021.11.007

Figure 4.

Figure 4

Visualization of spatiotemporal changes of risperidone (RISP) and its metabolite 9-hydroxy-risperidone (9-OH RISP) in brain tissues after i.p. administration using MALDI MSI with CHCA-LACT. (A) Ion images of RISP and 9-OH RISP were acquired at different time points. (B) Chemical structures of RISP and 9-OH RISP, and optical image of the horizontal section of the mouse brain. (C) Comparison of relative intensities of RISP and 9-OH RISP at different brain regions determined by LC‒MS/MS and MALDI MSI with CHCA-LACT, respectively. (D) Comparison of relative intensities of RISP and 9-OH RISP in the lateral ventricles at different time points determined by LC‒MS/MS and MALDI MSI with CHCA-LACT, respectively. The results were expressed as the mean ± SD from three animals.